glutathione in ros Reactive Oxygen Species (ROS) Metabolic Disease—Don't Shoot the Metabolic Messenger Mathematical model for glutathione dynamics

Tumor suppressor p53, known as the guardian of the genome, contains 12 Cys residues in its amino acid sequence [27], and oxidation of some of these inhibits p53 function [28]

[36] [37] Chinese herbal remedies: Jin Bu Huan, Ephedra, Shou Wu Pian, Bai Xian Pi

We have already discussed the fundamental role of GSH in avoiding ROS accumulation leading to cancerous transformation, as well as its crucial role in tumor cells survival

It is important to mention that these O 2 levels do not represent the concentrations found inside human healthy and cancerous tissues and are followingly used to investigate the different therapeutic efficiency of the nanoparticle formulation in high and low O 2 atmospheres

Therefore, in order to contextualize the complexity of the metabolic network and the impact of Gclc on it, we analyzed our transcriptomic data using Compass, a flux balance analysis-based approach that allows the characterization and interpretation of metabolic diversity at the single cell level 70,71