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GSH and pyroptosis Pyroptosis is a form of lytic cell death characterized by gasdermin-mediated plasma membrane pore formation, leading to osmotic swelling, membrane rupture, and the release of mature pro-inflammatory cytokines, including interleukin 1 beta (IL1B, also known as IL-1) and interleukin 18 (IL18)

Some research indicates that lithium may enhance the activity of glutamate-cysteine ligase, a rate-limiting enzyme in glutathione synthesis, but the exact molecular interactions remain unclear

Mice overexpressing a-synuclein showed accumulation of Ser129-phosphorylated a-synuclein on the injection side, and TLK2 KO significantly reduced this increase (Fig

Instead, glutamate was generated by metabolic conversion of glutamine, which we quantified using [ 13 C]glutamine

In Ophthalmic signs in practice of Medicine