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Together, these are known as cobalamins

The dosage chart presented here provides a framework, but the clinical nuances, specifically the titration pace, the dose ceiling, the choice of synergistic agents, and the biomarker monitoring schedule, should be individualized by a physician familiar with both the patient's metabolic history and the evolving evidence base for mitochondrial peptide therapy

doi: 10.1038/jcbfm.2010.23 113 LangstonW.CircuM

J Med Chem 62:27082719 Whittaker SJ, Demierre M-F, Kim EJ, Rook AH, Lerner A, Duvic M, Scarisbrick J, Reddy S, Robak T et al (2010) Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma

It is summarized here for completeness because subsequent work, including Sun et al