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Drug efflux from cells is mediated by the activity of transporter proteins, i.e., P-glycoprotein (Pgp), transporters of the MRP family, and some other proteins (Table 3)

Taken together, our results demonstrate that lipid peroxidation induces iron overload in iRPE cells and that TF protects these cells from the oxidative, inflammatory, and ferroptotic damage induced by 4HNE, which recapitulates the features of GA