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A more reliable technique is to reduce (knockdown) expression of the gene product, which can be achieved with RNA interference therapies that use a cells own machinery for regulating protein expression or with antisense oligonucleotides (ASO)

Zhang H, Yue X, Chen Z, Liu C, Wu W, Zhang N, et al

Posakony, J

doi: 10.1111/ene.15934 203

However, while current findings are encouraging, more rigorous clinical trials are essential to confirm their efficacy, determine optimal dosages, and assess long-term safety profiles