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Recently, biosensors have advanced to enable high-throughput measurement of target molecule in vivo

PMID 33931001

Bouchama A, Abuyassin B, Lehe C, Laitano O, Jay O, OConnor FG, et al

10.1104/pp.110.155804 Plant Physiol

Iron can enter the cell via transferrin 1 receptor (TfR1, also known as TFR1) and be reduced from ferric (Fe 3+ ) to ferrous (Fe 2+ ) form via metalloreductase STEAP3 in the endosome (Zhang et al., 2012)