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doi: 10.3390/molecules29040903 190 CookDAStephensonCRWilkinsonJMMaloneySFooJ

It was reported that podocyte-specific loss of PHB2, a mitochondrial inner membrane structural protein led to early onset of proteinuria in 3-weeks and death after 5 weeks 45

However, chronic damage (such as that caused by aging or metabolic stress) leads to a persistent inflammatory microenvironment that promotes tumor progression or aging-related diseases (90,109,110)