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Excessive differentiation of preadipocytes into mature adipocytes increases adipocyte number and size, ultimately leading to obesity

Obe et al., 2010)

This proposal would also provide payment limit stability that could help avoid potential access issues for providers and beneficiaries that could otherwise occur if we were to calculate a payment limit for a drug with negative or zero manufacturer's ASP data that is far below the provider's cost for acquiring the drug

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