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In parallel, Ca 2+ dysregulation, endoplasmic reticulum stress and mitochondrial dysfunction further exacerbate astrocytic impairment 114

We confirmed this observation in more independent data sets on melanoma and colorectal cancer (Figure 7B)

3.4.2 Patient 8progressive multifocal leukoencephalopathy (PML) Presentation: A female patient in her fourth decade with known MS, treated with natalizumab, who became John Cunningham Virus (JCV) positive