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One study showed that oxycodone, primarily metabolized by CYP3A4, combined with ethanol (0.3 or 0.6 g/kg), resulted in a significant reduction in peak BAC compared to ethanol alone (280)

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The median change in stroke volume during the three time points did not differ between the two groups ( p 2 mmol/l), with stroke volume change following passive leg raising over 10% (preload dependency), and with no contraindication to a nasogastric tube