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Sun et al., in their study, identified the key role of Kla in the immunosuppressive microenvironment and treatment resistance of pancreatic ductal adenocarcinoma (PDAC), where high levels of Kla in PDAC are associated with an immunosuppressive TME, resulting in a reduction in CTLs (96)

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Thus, increases in GSH levels could be beneficial to the activation of HTLV-1-specific CD8 + T cell and to the elimination of HTLV-1-infected cells [19]