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doi: 10.1111/anae.15606 [PubMed] 35131079 Walker A, Rupal A, Jani C, Al Omari O, Singh H, Patel D, Perrino C, McCannon J

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Side Effects and the Copper Uglies Explained GHK-Cu has a strong safety profile in topical research, but a small subset of users experience a transient phase known as the copper uglies. A 2023 clinical safety review covering 12 studies and 512 participants reported that the most common side effects of topical GHK-Cu were transient and mild

With allergies to any of the ingredients Take medications called nitrates, often prescribed for chest pain, or guanylate cyclase stimulators like Adempas (riociguat) for pulmonary hypertension as your blood pressure could drop to an unsafe level