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Another subtype, the GFAP-negative and -SMA (smooth muscle actin)- negative Type 2 astrocytes dominate the myelinated postlaminar region of the ONH (94) where they coexist with a subset of recently discovered GFAP- -SMA+ lamina cribrosa cells that may weaken the ONH through dysfunctional synthesis of collagens, elastin and fibronectin (95)