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259 Apart from immune cells, -3 PUFAs are crucial in regulating stromal cell functions (Table 1)

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Although aging, pathological calcification, and cancer present distinct pathological features, they share common mechanisms such as ECM stiffening driven by LOX/LOXL crosslinking, chronic inflammation and SASP activity, as well as EVs and protease-mediated remodelling

2 Safety Caffeine and beta-alanine are the most widely used ingredients included in pre-workout supplements found in 86% and 87% of products, respectively

Next, we assessed HR in mammalian cells