Mechanistically, G9a drives ferroptosis by epigenetically suppressing anti-ferroptosis genes
Theoretically, the export of both types substrates is possible from chloroplasts as the transamination (and also deamination reactions) of keto acids could be catalyzed by both chloroplastidic BCAT3 ( in vitro were not successful till now, as the direct measurements of transport of these substrates in artificial membranes is problematic due to higher hydrophobicity of substrates leading to unspecific membrane binding and permeation, which override the specific transport events ( PAPS/PAP ANTIPORTER IN CHLOROPLASTS Along with the BAT5, which exchanges 2-keto acids between chloroplast and the cytoplasm, the chloroplastidic transporter of activated sulfate (PAPS), which is essential for the sulfation of GSLs, flavonols, peptides, and other sulfated compounds in the cytoplasm has been recently identified ( Figures 1 and 2 , transporter 5)
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further showed that LXs alter the subcellular localization of 5-LOX, redirecting its activity from nuclear LTB4 synthesis to cytoplasmic LX production, suggesting that PRLMs may exert anti-inflammatory effects through spatial regulation [145]
Technological limitations also persist, as non-invasive methods for assessing oxidative stress in the human brain during sleep are still under development, restricting real-time, in vivo observations
