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however, glutathione is significantly depleted in hepatocytes during SNMP, which is probably attributed to the hepatocytes inability to overcome the threshold energy necessary for glutathione synthesis under subnormothermic conditions (145)

Teleanu DM, Niculescu A-G, Lungu II, Radu CI, Vladcenco O, Roza E, et al

Given that memantine, the glutamate receptor agonist, shows clinical relevance it is now timely to research related pathways, an understanding of which could identify novel approaches to treatment of AD