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An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents

Relevant data from these studies is shown in Table 1

During the development of osteoarthritis, the synovium undergoes interstitial vascularization, fibrosis and hyperplasia (167), and macrophages and fibroblasts in the synovium can release proinflammatory cytokines, etc., which cause synovitis and cartilage degeneration

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In contrast, NPC-like populations demonstrated enrichment in amino acid metabolism (seleno-aminoacids, alanine, aspartate, glutamate) and nitrogen catabolism (Fig