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As a result, critical information regarding the exact compounds used, dosages, duration of exposure, cycling patterns, and the concurrent use of additional substances in multi-drug regimenswhether intentional or unintentionaloften relies on retrospective self-reporting by users, which is inherently subject to recall bias and misclassification

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The representative chemiluminophores HCL1 and HCL5 with crosstalk-free emissions at 725 nm and 1025 nm are then respectively caged with NAG- and O 2 -responsive moieties and hooked together through a renal clearance unit to obtain a unimolecular cascaded activatable reporter CAR