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69,70,71,72 In synergy with TNF-, IL-4 enhances the expression of vascular cell adhesion molecule-1 and P selectin on vascular endothelial cells, facilitating the trans-endothelial passage of eosinophils from the blood into the respiratory system

In addition to the traditional perforingranzyme and FasFas ligand cell death induction pathways, interferon- secreted by CD8+ T cells activated in antiPD-L1 therapy can down-regulate System X c expression to reduce cystine uptake and induce ferroptosis (152)