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2026;4:1010132 DOI: Received: July 20, 2025 Accepted: March 18, 2026 Published: April 13, 2026 Academic Editor: Amnart Poapolathep, Kasetsart University, Thailand The article belongs to the special issue Neuroprotective Potential of Natural Products from Foods Aim: This study evaluated the comparative effects of commonly consumed artificial and natural sweeteners on cognitive function, neurotransmitter-related enzyme activities, and oxidative stress status in the brains of Wistar rats to elucidate their potential neurotoxic or neuroprotective properties under sub-chronic dietary exposure