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Of note, the commercial Iscoves Modified Dulbeccos Medium (IMDM) and Serum Free Expansion Medium (SFEM), which were used as the basal medium for erythroblast cultures, contain a supraphysiological concentration of cystine at 292 M as compared to physiological plasma concentration of 4075 M cysteine in SCD patients, which decreased further to 3060 M during vaso-occlusive pain episodes 36

10.1631/jzus.B2100748 54 EatonJ

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Even though it was previously stated that oral glutathione supplementation is not very effective, research does suggest that it works in some settings

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