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Pre-fixation was done with 2.5% glutaraldehyde phosphate (0.1 M, pH 7.4) overnight at 4 C

NayakBDahmouneFMoussiKReminiHDairiSAounOet al

Berberine Berberine, a naturally occurring alkaloid with a long traditionally history in Chinese and Native American medicine, is well known for its ability to arrest cell cycle and induce apoptosis in many different cancer cell lines

doi: 10.1038/nrm2275 29 DewaeleM.MaesH.AgostinisP

In the prefrontal cortex, increased TDO and KMO expression alongside reduced IDO and KAT shifts metabolism toward QA production, while cerebellar KYNA levels inversely correlate with symptom severity, linking KP dysfunction to 5-HT metabolism and clinical features [235]