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Oral and topical treatment of painful diabetic polyneuropathy: practice guideline update summary: report of the AAN Guideline Subcommittee

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Moreover, an aged-garlic extract (AGE)-derived compound, allicin (40 M), led to decreased basal GSH levels in leukemia cell lines [77] and colorectal cancer [78]

The glyoxalase pathway involves glyoxalase enzymes which metabolise methylglyoxal (MG), a toxic metabolite that accumulates with age and may contribute to neurodegeneration [110]