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Considering non-specific NSAIDs (24) (diclofenac, aspirin, ibuprofen, aspirin, paracetamol) (an immediate effect of both sphincters) versus specific NSAID, celecoxib, we evidenced that celecoxib affected firstly lower esophageal sphincter, and then, after a day, the pyloric sphincter as well

At present, GA derivatives have also been applied to the food industry and pharmaceutical industry, which also provides a better choice for the treatment of some diseases

It inhibits the NF-B and MAPK signaling pathways by activating the SIRT1 deacetylase, reduces ROS production, and delays chondrocyte apoptosis (48)

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