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Mice were dropped individually into glass cylinders which had a height of 25 cm and diameter of 10 cm, were filled with 10 cm of water (water level was marked to ensure uniformity), and maintained at a temperature of 23-25 C

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It has been used to treat some nutrition based disease such as dementia, rheumatoid arthritis and exerts neuronal protection by promoting regeneration to injured nerves

doi: 10.3389/fendo.2024.1390013 Received 22 February 2024 Accepted 22 July 2024 Published 02 August 2024 Volume 15 - 2024 Edited by Katja Teerds, Wageningen University and Research, Netherlands Reviewed by Wen-Xiang Liu, Inner Mongolia University, China Avi Lerner, Imperial College London, United Kingdom Updates Copyright 2024 Wang, Zhang, Ma, Xu, Zhao, Zhang, Li, Zhou and Zheng

The vitamin B 12 -dependent enzyme methionine synthase converts homocysteine and 5-methyltetrahydrofolate into methionine and tetrahydrofolate