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As well as chemical targeting, enzymatic targeting is another challenging strategy and cyst(e)inase-mediated depletion of serum cysteine and cystine pools has already been demonstrated to suppress the growth of tumours in different animal models

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The concurrent utilization of PD-1 and CTLA-4 may potentially yield synergistic alleviation of inhibition and complementary elimination The initial concerns regarding the potential for ICIs to trigger viral outbreaks in HCC patients with HCV or HBV were addressed in the first pivotal trials, which unequivocally demonstrated the safety of ICIs in these populations

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