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DOI: 10.1155/2012/358176 45

Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design

In fact, metformin, an AMPK-activating drug, and frontline treatment for type 2 diabetes, also increases PGC-1 expression and mitochondrial biogenesis [133]