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Moreover, loss of sex hormones has been suggested to promote an accelerated aging phenotype eventually leading to the development of brain hypometabolism, a feature often observed in menopausal women and prodromal Alzheimers disease (AD)

Critical role of Astrocyte NAD(+) Glycohydrolase in myelin injury and regeneration

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found that the downregulation of MFN2 but not MFN1 leads to the polarization of macrophages toward the M2 phenotype to promote renal fibrosis through mechanisms that inhibit macrophage mitophagy and dysfunctional mitochondrial dynamics (163)

doi: 10.1074/jbc.M608888200 149 NackenWSorgCKerkhoffC