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In db/db T2D-like diabetic mouse islets, the mTOR to AMPK switch is reversed and associated with a loss of oxidative metabolism and de-differentiation of -cells (Jaafar et al., 2019)

Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer

These authors found that toxic IAPP oligomers initially appear within the granules in the secretory pathway, where they disrupt the membranes of the granules, leading to their release into the cytoplasm