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Cell culture Human GBM cell lines U373-V (MGMT-low, +MMR) and U373-M (+MGMT, +MMR) and human colorectal cancer cell line HCT116 (MGMT-low, MMR) were used in this work

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Hence, considering the dual role of ferroptosis in tumor cell death and immunosuppressive phenotypes, how to optimize the therapeutic benefits of ferroptosis in different cancers by balancing ferroptosis and overcoming immunosuppressive phenotypes still requires to be clarified