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Literature data supported the potential role of mitochondrial dysfunctions (i.e., altered ATP production) in the onset of CFS symptoms such as fatigue and post exertional malaise (Morris and Maes 2014)

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For example, research published in Obesity indicated some modest weight reduction effects in overweight individuals

Biosci Biotechnol Biochem 64:244247

Rb1 reduces Ca 2+ leakage caused by overactivated ryanodine receptor 2 (RyR2) and increases Ca 2+ uptake by sarcoplasmic reticulum Ca 2+ -ATPase 2a (SERCA 2a)