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Description

This study provides histopathological characterization of human disc degeneration, describing the microscopic changes that correlate with clinical symptoms and imaging findings

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Several molecular mechanisms have been identified that may explain resistance and increased invasion after anti-angiogenic therapy in glioma, including mesenchymal transition of tumor cells, up-regulation of pro-angiogenic factors, activation of MET and up-regulation of MMPs [293,294,295,296]