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3.4 Nucleic acid A characteristic of the TME is high levels of extracellular nucleotides, which are metabolized through the dynamic and sequential action of cell surface enzymes, also known as ectoenzymes (96)

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In the I-SPY2 trial, the cohort with HR+/HER2 tumors revealed that combining neoadjuvant pembrolizumab with chemotherapy effectively increases the pCR rate