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The larger of the two studies (METAOD006), which included over 500 subjects at up to 1mg/daily AOD-9604, reported the following side effects: Any adverse event: 78.7% vs

Hydroxocobalamin has a longer retention and is used for specific patient needs

Early studies in obese individuals and animal models have shown it has potential to improve metabolic flexibility and support body fat loss, though further research is needed

Safety depends on the specific peptide, dosage, treatment goal, medical history, and whether the peptide is FDA-approved, used off-label, or investigational

For people who cannot tolerate GI side effects or who have medical conditions that make GLP-1 agonists risky, this safety differential is not a minor footnote