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Compared with the neutral antagonist-bound structure, the side chain of R283 6.55 has an obvious swing toward TM5 in the ghrelin-bound structure and appears to trigger local rearrangement of the TM6 bundle

PMID: 37626334 Nat Plants2022 Jul;8(7):792-801

7 dropped out due to side effects or loss to follow-up

Such abnormalities are discussed below in detail

Recent studies have also investigated clinical implications of GS, including its association with metabolic associated steatotic liver disease, cardiovascular disease, mental health and mortality risk, highlighting the complex interplay between genetic factors, bilirubin metabolism, and clinical outcomes