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Collectively, our findings reinforce that OCTN2 functions as a highly selective, high affinity transporter, mediating carnitine uptake via a Na + -dependent mechanism that, to our knowledge, has not been observed in the SLC22 family or in MFS transporters more broadly

Indeed, we demonstrated that: (1) in our adult COVID-19 patients, low VD status contributes to the worsening systemic inflammation among NS

Notably, these mice showed substantial improvements in motor coordination compared with controls

& Eriksson, L

The second strategy uses genetic engineering to introduce amino acid changes at specific positions of a cloned gene to identify regions critical for protein function