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Following pseudobulk aggregation, the data were normalized and log transformed, with the top most highly variable genes identified on the basis of mean expression and dispersion

280 Furthermore, activation of the inflammation-related NLRP3 inflammasome signaling pathway in different types of neural cells was closely associated with high cholesterol load, which triggered neuroprotective properties in activated microglia but promoted oxidative stress in neurons, further enhancing the expression of NLRP3 inflammasomes, inducing neuronal pyroptosis, and impairing the phagocytic capacity of microglia

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doi:10.1016/j.ejphar.2015.11.048 Tan SW, Israf Ali DAB, Khaza'ai H, Wong JW, Vidyadaran S