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Table 1 Efficacy comparison of Levodopa and DBS across clinical parameters including symptoms, side effects, and cost

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doi: 10.1080/10937404.2023.2300786 212 Ferreira JuniorRSMoralesMMBarrettiPBarravieraB

Endocannabinoids travel retrogradely and activate CB1 receptor, a G-protein coupled receptor located mainly on presynaptic terminals, resulting in short or long term decreases in GABA release (Piomelli, 2003