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Vascular endothelial growth factor (VEGF), a typical marker of angiogenesis during wound healing, was quantitatively assessed via ELISA on day 3, revealing a significant increase in the G/D-CuP group (Fig

Nonetheless, due to a deficit in the autophagy machinery, most altered mitochondria cannot be taken up by autophagosomes, and they appear partially enwrapped by the limiting autophagosomal membranes

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Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

Taken together with the clinical timeline, dechallenge response, and exclusion of alternative causes, these findings indicate that moxifloxacin best fulfills the criteria for the principal offending drug in this case (complete itemized scores and supporting evidence are provided in Supplementary Tables 3, S4 )