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Similarly, in renal cell carcinoma, berberine treatment increases ROS levels and apoptosis rates, accompanied by the protein upregulation of Bax, Bad, Bak, Cytochrome, the downregulation of Bcl-2c and activating Caspase-3, and Caspase-9 [219]

Closer evaluation of the protein classification list (Extracellular Matrix Protein) revealed unique enrichment of Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) in ExerVs, a factor that maintains TGF1 in a latent or inactive state 48

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These effects on collagen synthesis and glycosaminoglycan production contribute to the overall structural changes observed in animal wound models (Pickart et al., 2015)