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Enebo LB, Berthelsen KK, Kankam M, et al

Research-Use Dosing Conventions (Not Clinical Guidance) The figures below are reported from published studies and, for tirzepatide, its approved label

Cagrilintide has no boxed warning because it has no approved label which reflects its investigational status, not proven long-term safety

Second, the strength of tirzepatides evidence is exactly what makes an apples-to-apples ranking against an investigational amylin analog impossible: you cannot fairly rank a fully-approved drug against a candidate whose stand-alone efficacy stops at Phase 2