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Melatonin, known for its antioxidant properties, also modulates the Nrf2 pathway, enhancing the expression of heme oxygenase-1 (HO-1), which strengthens antioxidant defenses in DN (Negi et al., 2011a)

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The Conformit Europenne - In Vitro Diagnostic (CE-IVD) mark, a regulatory framework issued by the European Union, ensures that commercial kits meet standards for traceability and reproducibility, thereby enabling clinical standardization across labs

386,387 The increased chemokine levels are possibly caused by LPS stimulation in T2DM patients, which can predict hepatic steatosis

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This model helped to explain why abacavir hypersensitivity is only observed in individuals expressing HLA-B*57:01 [193] and abacavir only activates CD8 + T-cells (abacavir is the only drug causing hypersensitivity reactions that doesnt activate CD4+ and CD8 + T-cells)