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There are three main sources that generates ROS for ferroptosis: 1) Mitochondria: Mitochondria serve as the primary source of ROS during oxidative phosphorylation, a process vital for cellular energy generation

The nature of the catalytic residue in the EF1B and Ure2p classes is less clear, but RIRT and APNG motifs are found at a position similar to the active site signature in other GSTs

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