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doi: 10.1007/s12551-020-00726-0 89 WangQMaLAnCWiseSGBaoS

JCI Insight 6 , e14457 (2021)

Ferroptosis pathways and therapeutic targets in spinal cord injury Targeting ACSL4/LPCAT3/15-LOX Proanthocyanidin significantly reduced ACSL4 and ALOX15 levels and increased GSH, GPX4, Nrf2, and HO-1 expression to inhibit ferroptosis and promote functional recovery from SCI (Zhou et al., 2020b)

The understanding of this mechanism was later derived from a separate study involving mice.

346,347,348 The first is the exogenous route, in which the NADs are directly introduced into the obtained exosomes via electroporation, co-incubation, sonication, extrusion, and freeze-thaw cycling