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Oidative stress plays an important role in pulmonary fibrosis, epilepsy, hypertension, atherosclerosis, Parkinson's disease and sudden death, and it is also known to be associated with a number of ophthalmic diseases, such as age-related macular degeneration, cataract and glaucoma (14,15)

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253,277 During COPD development, the neutrophils and alveolar macrophages are activated to produce various inflammatory mediators, including IL-1, IL-6, IL-8 and TNF-