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Moreover, mitochondrial-derived ROS and mitochondrial DNA damage may activate inflammatory signaling pathways, reinforcing the chronic inflammatory microenvironment [40]

Metallothionein: metal-binding protein and more Metallothioneins (MTs) are ubiquitous low-molecular-weight, cysteine-rich proteins that can bind metals via mercaptide bonds

reported that the circular RNA circKIF4A, which is overexpressed in PTC, enhances cancer cell proliferation and migration by inhibiting apoptosis (64)

These data suggest that human immunization strategies for SARS-CoV-2 that elicit high neutralizing antibody titres have a high chance of success with minimal risk of ADE