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Importantly, both interventions increase both lifespan and healthspan without apparent major fitness trade-offs, in contrast to those previously reported in long-lived mutants that do slow the rate of ageing 39, 40

Ramanathan RK, Abbruzzese J, Dragovich T, Kirkpatrick L, Guillen JM, Baker AF, et al

In neurodegenerative diseases such as AD and PD, abnormalities in energy metabolism result in insufficient glucose uptake and mitochondrial dysfunction, leading to inadequate energy supply and oxidative stress

Since then, it has become a key area of interest in life science research

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