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Collectively, these findings indicate that the heightened sensitivity of PC-9 and NCI-H1975 cells to Cu-DMSA-HA NPs results from the combined effects of efficient CD44-mediated NP uptake, increased ferroptosis susceptibility, and diminished intrinsic antioxidant capacity

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[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Yang S.L., Tan H.X., Lai Z.Z., Peng H.Y., Yang H.L., Fu Q., Wang H.Y., Li D.J., Li M.Q

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The concept of immunogenic necrotic cell death proposes to trigger an autoamplification loop, which is triggered by a necroinflammatory microenvironment