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Second, amplification of pro-inflammatory cytokine response in macrophages by S100A8/S100A9 complex is via activation of MAPK and NF-B signaling (128)

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This is partly due to the bodys attempt to compensate for the lack of estrogen by increasing fat storage, as fat cells can produce a small amount of estrogen

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(December 18, 2013), Williams and Djokovic named 2013 ITF World Champions Archived April 29, 2016, at the Wayback Machine "Serena Wins Best Female Athlete ESPY"