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Studies also show that approximately 85% of the population is deficient in B12, and oral supplements are often ineffective in correcting this deficiency

This research shows B12 is important in treating depression

The interest traces to a 2014 Nature paper showing that knocking down NNMT in fat and liver protected mice against diet-induced obesity, glucose intolerance, and fatty liver, partly by shifting adipose NAD+ and SAM levels [4]

Conditions that can cause B12 depletion include: Celiac disease a severe reaction to eating gluten-containing grains Gastritis inflammation of the stomach lining